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Given that thousands of new chemicals are introduced each year, most of which are untested for developmental neurotoxicity, it seems unlikely that exposures to such toxicants will decline. Here, we focus on a strategy that may be more readily applicable to neurodevelopmental disorders, namely dietary manipulation in which the majority of calories are derived from fat (i.e., a “ketogenic” diet). Interestingly, the same approach has been tried in treating attention deficit hyperactivity disorder and autism in pilot studies (Connolly et al. 2005); notably, in keeping with the pilot human studies, high fat diets ameliorate behavioral anomalies in genetically modified mice (Teegarden et al. The ability of dietary manipulations to evoke widespread changes in neuro transmitter function is likely due to changes in the composition of membrane lipids in which receptors and cell signaling molecules are embedded (Gudbjarnason and Benediktsdottir 1996; Ponsard et al. ….

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Given that thousands of new chemicals are introduced each year, most of which are untested for developmental neurotoxicity, it seems unlikely that exposures to such toxicants will decline. Here, we focus on a strategy that may be more readily applicable to neurodevelopmental disorders, namely dietary manipulation in which the majority of calories are derived from fat (i.e., a “ketogenic” diet). Interestingly, the same approach has been tried in treating attention deficit hyperactivity disorder and autism in pilot studies (Connolly et al. 2005); notably, in keeping with the pilot human studies, high fat diets ameliorate behavioral anomalies in genetically modified mice (Teegarden et al. The ability of dietary manipulations to evoke widespread changes in neuro transmitter function is likely due to changes in the composition of membrane lipids in which receptors and cell signaling molecules are embedded (Gudbjarnason and Benediktsdottir 1996; Ponsard et al. ….

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